p-Toluenesulfonylurea (PTSU) CAS 1694-06-0
Product Data
| Item | Details |
|---|---|
| Product name | p-Toluenesulfonylurea |
| Abbreviation | PTSU |
| CAS number | 1694-06-0 |
| EC number | 216-900-3 |
| Other names | 4-Methylphenylsulfonylurea; N-(p-Toluenesulfonyl)urea |
| Molecular formula | C8H10N2O3S |
| Molecular weight | 214.24 g/mol |
| Physical form | White to off-white powder or crystalline solid |
| Main applications | Gliclazide and tolbutamide intermediates |
PTSU for Sulfonylurea Intermediate Manufacturing
The terminal urea functionality of PTSU participates in the coupling reactions used in downstream sulfonylurea synthesis. In gliclazide production, the p-tolylsulfonylurea portion is retained in the resulting pharmaceutical molecule.
The product is intended for further industrial chemical processing. Typical buyers include pharmaceutical intermediate producers, API manufacturers and commercial distributors serving these manufacturing operations.
Solvent Characteristics
PTSU is soluble in dimethylformamide and dimethyl sulfoxide, with limited solubility in acetone and methanol. This solvent profile is relevant to solution preparation and solvent-based processing of the intermediate.
Applications in Pharmaceutical Synthesis
Gliclazide Manufacturing
PTSU is an intermediate in gliclazide synthesis. In a direct coupling route, it reacts with the bicyclic N-amino intermediate to form gliclazide. PTSU supplies the p-tolylsulfonylurea portion of the resulting molecule and enters the process at the coupling stage.
An alternative route uses PTSU to prepare a hydrazine-derived intermediate. Subsequent reaction with cyclopentane dicarboxylic anhydride and reduction produces gliclazide. Both routes use PTSU as a chemical building block in further synthesis; the reaction sequence differs between manufacturing processes.
Tolbutamide Intermediate
PTSU is also used as an intermediate in tolbutamide synthesis. Its application is in routes based on this sulfonylurea building block. It is purchased as a chemical input for further industrial conversion.
Storage and Handling
Store in tightly closed containers in a cool, dry and ventilated area, away from heat sources. Avoid dust exposure during transfer and production charging. Use appropriate local extraction and personal protection in accordance with the product SDS and site handling procedures.
Supplier Support for Your PTSU Purchase
For industrial PTSU purchases, Unilong helps coordinate supplier assessments, pre-shipment checks and export arrangements. Our support gives your purchasing and quality teams practical ways to assess the supply source and proposed shipment.
Factory Visit and Audit Coordination
We assist with production-site visits and audit appointments for customer supplier assessments. Visits are subject to the production site's approval and scheduling. Your team or appointed auditor conducts the assessment, with Unilong assisting with site communication.
Pre-Shipment Sample Approval
For orders with agreed pre-shipment sample approval, the cargo remains on hold until you approve release. Your quality team can assess the sample before authorizing dispatch of the bulk shipment.
Independent Pre-Shipment Inspection
Third-party inspection can be arranged on request. The agreed inspection gives your team an independent check of the shipment before dispatch, with the inspection scope and charges established for the order.
Export Packing and Shipment Coordination
Our team coordinates packing and transport arrangements for industrial orders. Unilong provides a contact point for communication about the shipment and delivery arrangements.
Discuss Your Supplier Assessment
Procurement FAQ
Who conducts a production-site assessment?
Your team or appointed auditor conducts the assessment. Unilong assists with site communication and visit coordination.
Can inspection address our purchase requirements?
Yes. The inspection scope is agreed for the order and can include checks specified in the purchase contract, subject to the inspection provider's capabilities.
Do you accept laboratory or standalone sample orders?
No. We serve industrial and commercial bulk procurement. Laboratory projects, research orders and standalone sample purchases are outside our supply scope.
Request a PTSU Bulk Quote
Contact Unilong for p-Toluenesulfonylurea CAS 1694-06-0 for your industrial production requirements.
