Calcium glycerophosphate (CAS 27214-00-2) supplies calcium and phosphorus in a single ingredient. It is used in mineral formulations and has been studied in fluoride toothpaste. Its value in each application depends on different properties. In nutrition, elemental mineral content matters. In toothpaste, the relevant evidence comes from the finished formula.
Ingredient Identity and Water Solubility
Calcium glycerophosphate is the calcium salt of glycerophosphoric acid. The commercial ingredient described by USP contains a mixture of glycerophosphate isomers and may contain water of hydration. USP calcium glycerophosphate monograph.
The FCC monograph reports a reference solubility of about 1 g in 50 mL of water at 25 °C. It also describes higher solubility at lower temperatures and an increase in solubility in the presence of citric acid. In an aqueous formula, the acid system, mineral loading and processing temperature therefore matter when setting a clarity target. FCC calcium glycerophosphate monograph.
Use in Toothpaste and Oral Care
In toothpaste development, calcium glycerophosphate has been evaluated as a calcium and phosphate source in fluoride formulations. A short in situ study compared low-fluoride toothpastes with and without added calcium glycerophosphate. In the tested formulas, adding the ingredient improved measures of remineralization on bovine enamel samples. The study measured enamel outcomes over short treatment periods. Zaze and colleagues, Journal of Dentistry, 2014.
The results apply to the tested formulas and study conditions. For a new toothpaste, the fluoride source, soluble fluoride over shelf life and compatibility with the abrasive system are relevant formulation checks. Any cavity prevention or remineralization claim depends on the evidence and regulatory requirements for the finished product.
Calcium and Phosphorus in Mineral Formulations
A mineral formula based on calcium glycerophosphate has two contributions to account for. Its anhydrous formula corresponds to approximately 19.1% elemental calcium and 14.7% elemental phosphorus by mass. These are theoretical values calculated from the molecular formula. The mineral contribution of the material as supplied depends on its measured composition and moisture. USP monograph and molecular formula.
This paired contribution matters in blends that already contain phosphorus or use more than one calcium source. A dry mineral blend is usually designed around the contribution per serving and the uniformity of the blend. In a liquid format, the available water and the behavior of the complete formula during storage also matter.
U.S. Food Use and Ingredient Grade
In the United States, 21 CFR § 184.1201 affirms calcium glycerophosphate as GRAS for the conditions of use described in that section. The rule covers its nutrient supplement function and use in specified foods such as gelatins, puddings and fillings, subject to current good manufacturing practice and the referenced identity and specifications. 21 CFR § 184.1201.
Food and supplement applications depend on the commercial grade and requirements of the destination market. The applicable grade documentation establishes which specification and test basis apply to the material offered for the project.
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Post time: Nov-10-2026