7-Ketolithocholic Acid (CAS 4651-67-6) for UDCA Synthesis
7-Ketolithocholic Acid Product Overview
Unilong supplies 7-Ketolithocholic Acid (CAS 4651-67-6), also known as 3α-Hydroxy-7-oxo-5β-cholanic Acid, for manufacturers sourcing intermediates for ursodeoxycholic acid (UDCA) and related bile acid synthesis. This steroidal bile acid derivative is used in established pharmaceutical intermediate manufacturing routes where the C7 keto group is required.
For commercial purchasing, Unilong can discuss your target assay, related-substance requirements, packaging preferences and order volume. Contact us with your specifications and delivery destination for a quotation.
Product Information
| Item | Product Details |
|---|---|
| Product Name | 7-Ketolithocholic Acid |
| Chemical Name | 3α-Hydroxy-7-oxo-5β-cholanic Acid |
| CAS Number | 4651-67-6 |
| Molecular Formula | C24H38O4 |
| Molecular Weight | 390.56 g/mol |
| EC Number | 225-083-2 |
| Other Names | 7-Oxolithocholic Acid; Nutriacholic Acid; 7-KLCA; 7-Keto-Lithocholic Acid |
| Appearance | White to off-white solid or crystalline powder |
| Product Category | Pharmaceutical Intermediate / Bile Acid Intermediate |
| Primary Application | Intermediate for UDCA and related bile acid synthesis |
| Commercial Packing Reference | 25 kg/drum; final packaging confirmed with quotation |
| Supply Specification | Assay and quality requirements to be agreed for the selected grade |
Looking for 7-Ketolithocholic Acid for commercial synthesis? Send Unilong your required grade, purchase quantity and destination to discuss material specifications and pricing.
7-Ketolithocholic Acid for Bile Acid Manufacturing
7-Ketolithocholic Acid belongs to the steroidal bile acid family. Its structure contains a 3α-hydroxyl group and a carbonyl group at the C7 position, making it a useful intermediate in chemical processes involving the conversion of bile acid derivatives.
In pharmaceutical intermediate manufacturing, this compound is principally associated with routes leading to ursodeoxycholic acid and other related bile acids. The carbonyl group provides a functional position for subsequent chemical conversion, while the cholanic acid framework is retained during relevant transformations.
For industrial production, the material is selected according to the intended synthesis route and the quality requirements of the receiving process. Purity, related substances, physical appearance and lot consistency are important considerations for repeat manufacturing.
Unilong supplies this material as a chemical intermediate for downstream manufacturing rather than as a finished pharmaceutical product.
Applications of 7-Ketolithocholic Acid
1. Intermediate for Ursodeoxycholic Acid (UDCA) Synthesis
7-Ketolithocholic Acid is a recognized intermediate in the chemical synthesis of Ursodeoxycholic Acid (UDCA, CAS 128-13-2).
In relevant production routes, the C7 keto group undergoes reduction to form a hydroxyl group. Formation of the required 7β-hydroxyl configuration is important for obtaining ursodeoxycholic acid. The selected reaction route and subsequent purification determine the composition and quality of the resulting material.
For manufacturers purchasing 7-Ketolithocholic Acid for UDCA production, Unilong can discuss material specifications suitable for the intended manufacturing process.
Commercial enquiries may include requirements for assay, individual and total related substances, loss on drying, and the desired purchasing quantity. These details help establish a suitable supply specification for continued production.
2. Intermediate in Chenodeoxycholic Acid and Related Bile Acid Routes
The C7 carbonyl functionality of 7-Ketolithocholic Acid also makes it relevant to chemical routes involving chenodeoxycholic acid (CDCA) and related bile acid intermediates.
In suitable reduction pathways, formation of the 7α-hydroxyl configuration leads toward chenodeoxycholic acid. The product distribution depends on the specific reaction conditions and downstream purification process.
Unilong can discuss 7-Ketolithocholic Acid requirements with manufacturers using this intermediate in established bile acid conversion processes.
When sourcing for these applications, customers may specify particular impurity limits, physical form requirements and batch quantities to match their production needs.
3. Intermediate for Obeticholic Acid Synthesis Routes
Published synthesis routes also identify 7-Ketolithocholic Acid as an upstream intermediate associated with the preparation of Obeticholic Acid (OCA) and related steroidal compounds.
Its use depends on the selected multistep synthetic route, including the transformations and purification operations required to obtain the downstream intermediate or final compound.
For companies manufacturing obeticholic acid intermediates, Unilong can discuss supply requirements for CAS 4651-67-6 according to the intended process specification.
This material is supplied as an intermediate and should be identified separately from obeticholic acid itself.
4. Manufacturing of Related Cholanic Acid Derivatives
7-Ketolithocholic Acid may also serve as a starting intermediate in the preparation of selected cholanic acid derivatives where its steroid framework and C7 carbonyl functionality are required.
These applications involve established chemical synthesis and intermediate manufacturing rather than direct use in finished pharmaceutical formulations.
Unilong welcomes commercial enquiries from manufacturers requiring this specific chemical structure for multistep production. Product identity, grade requirements and order quantities can be discussed before quotation.
Quality and Specification Requirements
Unilong can discuss commercial specifications for 7-Ketolithocholic Acid according to the intended downstream manufacturing requirements. The following quality parameters may be included in a product specification:
| Quality Parameter | Supply Discussion |
|---|---|
| Appearance | White to off-white solid or crystalline powder |
| Identification | Product identity corresponding to CAS 4651-67-6 |
| Assay / Purity | Confirm the required grade and analytical basis |
| Related Substances | Individual and total impurity requirements |
| Loss on Drying / Moisture | Limits according to the selected specification |
| Residue on Ignition | Requirement where applicable |
| Residual Solvents | Limits and supporting information where applicable |
| Batch Documentation | Confirm available documentation for the selected material |
The final specification is established against the grade being quoted.
For manufacturers operating established bile acid synthesis routes, the required quality profile may vary according to the starting material, chemical transformations and purification process. Unilong can review these commercial requirements before confirming a quotation.
Material Consistency for Repeat Manufacturing
Repeat purchases may require a defined product identity, consistent physical form and agreed quality limits across successive deliveries.
For manufacturers purchasing this intermediate for ongoing production, Unilong can discuss the expected purchasing schedule, target specification and documentation requirements as part of supply planning.
Where a specific impurity limit or analytical method is mandatory, the requirement can be included in the product enquiry so that the offered material can be evaluated against the intended specification.
Packaging and Bulk Supply
7-Ketolithocholic Acid is commercially handled as a solid chemical intermediate. Packaging reference: 25 kg/drum.
For orders through Unilong, the final drum configuration, inner packaging, net weight and available alternatives will be confirmed in the quotation.
Commercial supply enquiries can cover:
- 25 kg drum packing requirements
- Alternative packaging configurations
- Production-order quantities
- Repeat purchasing schedules
- Delivery destinations and shipment arrangements
Order quantity, grade and packaging requirements are considered together when preparing a quotation.
For production planning, customers can provide the required shipment quantity and purchasing schedule. Unilong can then discuss the applicable commercial terms.
Storage and Handling
Keep 7-Ketolithocholic Acid in securely closed containers in a dry, suitably controlled storage area. Protect the material from direct sunlight, excess moisture and unnecessary exposure to heat.
Maintain the original packaging until the material is required for production. After opening, ensure the container is properly resealed to reduce exposure during storage.
Storage and handling arrangements should follow the safety and technical information applicable to the supplied grade.
Transport packaging and shipment conditions are confirmed according to the material offered and the delivery destination.
Product Documentation and Commercial Supply
For manufacturers evaluating 7-Ketolithocholic Acid as a production intermediate, Unilong can discuss the quality and commercial information required for material approval and purchasing.
Depending on the selected supply grade and available records, documentation requirements may include a batch Certificate of Analysis (COA), Safety Data Sheet (SDS), technical specifications and relevant material information.
The availability and scope of documentation can be confirmed for the proposed product and batch.
For ongoing procurement arrangements, commercial discussions may also cover the required purchasing volume, packaging configuration, delivery schedule and destination.
Why Contact Unilong for 7-Ketolithocholic Acid?
Unilong works with chemical manufacturers and industrial purchasing teams sourcing fine chemicals and intermediates.
For CAS 4651-67-6, our commercial team can coordinate enquiries covering:
- Product identity and intended manufacturing application
- Required assay and impurity specifications
- Commercial packaging requirements
- Bulk-order quantities and purchasing schedules
- Documentation needs and delivery arrangements
We focus on clear communication of the material specification and commercial requirements so that quotations can be prepared for the intended manufacturing application.
Contact Unilong for a 7-Ketolithocholic Acid quotation.
Frequently Asked Questions
What is 7-Ketolithocholic Acid used for?
7-Ketolithocholic Acid is used primarily as an intermediate in bile acid synthesis. Important applications include chemical routes to ursodeoxycholic acid and related pharmaceutical intermediates. It is also associated with selected chenodeoxycholic acid and obeticholic acid synthesis routes.
Is 3α-Hydroxy-7-oxo-5β-cholanic Acid the same as 7-Ketolithocholic Acid?
Yes. These names refer to the same compound under CAS 4651-67-6. It is also known as 7-Oxolithocholic Acid and 7-KLCA.
Is 7-Ketolithocholic Acid the same material as Ursodeoxycholic Acid?
No. 7-Ketolithocholic Acid (CAS 4651-67-6) is an intermediate that can be converted into ursodeoxycholic acid (CAS 128-13-2) through suitable chemical transformations. The two materials have different chemical structures and CAS numbers.
What purity of 7-Ketolithocholic Acid can Unilong quote?
Please provide your required assay or purity grade, along with any individual impurity, total impurity, moisture or residual solvent limits that apply to your production process. Unilong can discuss the corresponding material specification and quotation.
Can 7-Ketolithocholic Acid be ordered in 25 kg drums?
A 25 kg drum is a commercial reference packaging format for this intermediate. Contact Unilong with your required order quantity to confirm the available packing configuration and delivery terms.
Can I request a COA or other technical documentation?
Please include your COA, SDS or technical documentation requirements in the enquiry. Unilong can confirm which documents are available for the proposed grade and supply batch.
Can Unilong discuss bulk quantities for UDCA production?
Yes. Unilong can discuss purchasing requirements for 7-Ketolithocholic Acid intended for UDCA intermediate manufacturing, including required grade, order volume, packing preferences and delivery schedule. Commercial availability and terms are confirmed through the quotation process.
What information should I include when requesting a quotation?
Please send the product name or CAS number, required grade, order quantity, destination and any essential specification or packaging requirements. Our sales team can use this information to discuss a suitable commercial offer.
Request a Quotation
7-Ketolithocholic Acid | CAS 4651-67-6
For pharmaceutical intermediate manufacturing and bile acid synthesis projects, contact Unilong to discuss product specifications, packaging requirements and commercial quantities.
Send your required grade, purchasing quantity and delivery destination to discuss a quotation with Unilong.
Email: sales@unilongindustry.com
