1,1,1,3,3,3-Hexafluoro-2-propanol CAS 920-66-1
1,1,1,3,3, 3-hexafluoro-2-propanol (HFIP) is an important fluorinated organic compound, also known as Hexafluoroisopropanol, with a CAS of 920-66-1 and a molecular weight of 168.038. 1,1,1,3,3, 3-hexafluoro-2-propanol is a colorless and transparent liquid with a pungent odor. 1 1 1 3 3 3 hexafluoro-2-propanol has strong hydrogen bonds, which can combine with most molecules and form stable complexes with various ethers and amines that are difficult to separate by fractionation. Hexafluoroisopropanol HFIP is stable under normal temperature and pressure, but it should be kept away from oxides.
Although 1,1,1,3,3,3-Hexafluoro-2-propanol has a certain viscosity, its boiling point is very low, and it usually needs to be analyzed at 40 ° C to reduce the back pressure of the chromatographic column. Hexafluoroisopropanol HFIP is also a highly polar solvent, which can cause the calibration curve obtained by the mixed column chromatography column to become nonlinear.
| Item | Specification |
| Boiling point | 59 °C(lit.) |
| Density | 1.596 g/mL at 25 °C(lit.) |
| Melting point | −4 °C(lit.) |
| flash point | 4,4°C |
| resistivity | n20/D 1.275(lit.) |
| Storage conditions | Store below +30°C. |
1,1,1,3,3,3-Hexafluoro-2-propanol can be used to prepare various high-end chemicals such as fluorinated surfactants, fluorinated emulsifiers, fluorinated pharmaceuticals, as well as solvents or cleaning agents for the electronics industry.
As a solvent: 1,1,1,3,3, 3-hexafluoro-2-Propanol is a highly polar solvent that can dissolve various polymers, such as polyester, polyamide, polyacrylonitrile, etc. Hexafluoro-isopropanol is often used in the analysis of these polymers and as a regenerant for the reuse of polymers. Hexafluoroisopropanol is also an excellent solvent for liquid-phase peptide chemistry and can be used for dissolving peptides and peptide intermediates.
For organic synthesis: Hexafluoroisopropanol cas number 920-66-1 can be used as an esterification reagent and also enhance the efficiency of rhodium (I) -catalyzed (4+2) intramolecular cycloaddition reactions of ether-bound alkynyl dienes and (5+2) cycloaddition reactions of alkynyl vinyl cyclopropanes.
Application in the electronics industry: Hexafluoroisopropanol can be used as a solvent or cleaning agent in the electronics industry.
Pharmaceutical intermediates: HFIP is a key starting material or intermediate for the synthesis of various fluorine-containing drugs. The introduction of fluorine-containing groups into drug molecules can significantly alter their lipid solubility, metabolic stability and biological activity. A well-known example is Sevoflurane, a widely used inhaled general anesthetic, which is synthesized from HFIP.
Usually packed in 25kg/drum,and also can be do customized package.
1,1,1,3,3,3-Hexafluoro-2-propanol CAS 920-66-1
1,1,1,3,3,3-Hexafluoro-2-propanol CAS 920-66-1
