Croscarmellose Sodium CAS 74811-65-7
Croscarmellose Sodium is a white to milky white, fine dispersed, almost odorless and tasteless hygroscopic powder. Croscarmellose Sodium is insoluble in water and common solvents, and has strong hydrophobicity and high hygroscopicity, swelling upon contact with water. Cross-linked sodium carboxymethyl cellulose can cause the tablet to disintegrate rapidly, increase the dissolution of the drug and improve its bioavailability.
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ITEM |
STANDARD |
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Identification |
A. The Croscarmellose Sodium absorbs the methylene blue and settles as a blue, fibrous mass, A. The Croscarmellose Sodium absorbs the methylene blue and settles as a blue, fibrous mass, C. A portion of the mixture of Croscarmellose Sodium with
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pH |
5.0~7.0 |
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Settling Volume |
The volume of the settled mass is 10.0~30.0 mL |
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Degree of Substitution |
The degree of substitution is 0.60~0.85 on the dried basis. |
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Sodium Cholride and Sodium Glycolate |
The sum of the percentages of sodium chloride and sodium glycolate is NMT 0.5%. |
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Content of Water-Soluble Material |
NMT 10.0% |
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Loss on Drying |
NMT 10.0% |
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Residue on Ignition |
14.0%~28.0% |
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Microbial Enumeration Tests and Tests For |
The total aerobie microbial count does not exceed 1000 cfu/g |
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Specified Microorganisms |
It meets the requirements of the test for absence of Escherichia colL |
1.In the field of medicine, cross-linked sodium carboxymethyl cellulose is one of the most important disintegrants in oral tablets and capsules. Its characteristic of "rapid water absorption and swelling without forming a gel barrier" can significantly enhance the dissolution efficiency of drugs.
2. As a food-grade auxiliary material (conforming to China's GB 2760 and the US FDA GRAS standards), CCMC-Na mainly plays the role of "thickening, stabilizing and improving taste".
3. Daily chemical industry: Toothpaste and skin care products
Adding 0.5% to 1.5% to toothpaste can serve as an "auxiliary abrasive component", enhancing the viscosity and plasticity of the toothpaste through water absorption and expansion. At the same time, croscarmellose sodium gently cleans the surface of teeth (avoiding scratching the enamel), and has good compatibility with components such as fluoride and surfactants (without affecting the release of fluoride ions).
Adding a small amount (0.1%-0.3%) to skin care products (such as masks and lotions) can act as a "moisturizing stabilizer", absorbing moisture in the air, extending the skin's moisture retention time, and it is light in texture without increasing the greasiness of the product.
25kgs/drum, 9tons/20’container
25kgs/bag, 20tons/20’container
Croscarmellose Sodium CAS 74811-65-7
Croscarmellose Sodium CAS 74811-65-7
